A PhD scholarship (3 years) in marine bacterial biotechnology is available at the National Institute of Aquatic Resources (DTU Aqua).
DTU Aqua is an institute at the Technical University of Denmark. The institute is involved in research, education and advice related to the aquatic environment. The institute has an international research staff comprising approx. 120 academic employees in aquatic and fisheries sciences, food technology and microbiology. The aquatic microbiology research focuses on microbial ecology, fish and human pathogens and bioactive marine bacteria.
The PhD project will focus on the influence of environmental parameters on the production of bioactive compounds (pigments, extracellular polymers, antibiotic active substances) from marine bacteria identified as species belonging to Pseudoalteromonas, Ruegeria and Vibrio. Also, the project will evaluate potential use of such compounds as inhibitory substances against pathogenic bacteria or as agents preventing biofilm formation. Potentially, the project will, in collaboration with the postdoctoral fellowship, probe into molecular aspects of the production of bioactivity, e.g. by generating transposon libraries and isolating non-producing mutants.
The PhD student will work closely with a postdoctoral fellow , other microbiologists at DTU Aqua and, with natural product chemists at DTU Systembiology that are in charge of extraction of bioactive compounds and structure elucidation. The project is part of a larger collaboration focusing on the collection of bacteria from Galathea 3 and their bioactive potential. This collaborative effort also involves scientists from University of Copenhagen, University of Southern Denmark, Chr. Hansen A/S and nature&science aps. The partners study other aspects of the bioactive bacteria, such as their interaction with immune cells or their specific interference with bacterial virulence.
Required skills for the PhD scholarship:
* A master’s degree (M.Sc.) in microbiology, biotechnology, civil engineering or a similar degree with an academic level equivalent to a master’s degree in microbiology
* A keen interest in research especially microbiology and the ability to be self motivated
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