A postdoctoral position is available starting Feb. 2010 at the Ian Wark Research Institute, the Australian Research Council Special Research Centre for Particle and Material Interfaces. The postdoctoral fellow will be appointed to an NH&MRC funded project entitled .
Project Description
While the presence of CTCs in blood has been known since the mid-1800s, their capture for diagnostic and mechanistic purposes has remained an elusive goal, mostly due to the absence of reliable technologies able to isolate these cells which are present at ratios as low as 1 to 10 per a billion blood cells. The capture and molecular analyses of these cancer cells offers unique possibilities to achieve a better and personalized understanding of the disease pathophysiology and to monitor its evolution. The recent demonstration of the outstanding capabilities of microfabricated devices to isolate CTCs has generated the hope of a real paradigm shift in cancer diagnostic, prognostic and mechanistic studies. Taking advantage of the unique new facilities at the Wark of the South Australian node of the Australian National Fabrication Facility, the aim of this project is to develop a microfluidic platform technology for the immuno-specific capture and molecular profiling of circulating cancer cells (CTCs) from blood. Through the integration on these CTC capture devices of advanced nanotechnology-enabled detection methods and molecular profiling capabilities such as FISH and RT-PCR, this project also aim to deliver practical and noninvasive strategies to determine the molecular signature of metastatic malignancies.
The appointee will be more specifically engaged in the development of state-of-the-art microfluidic-based devices for the capture and analyses of circulating tumour cells. The appointee will liaise closely with partners in biological sciences including an established molecular biology team. We are looking for talented, self-motivated individuals with a strong background in Microfluidic/Microfabrication and their biological applications. They should be enthusiastic about designing new biophysical methods to biological problems. Candidates with a background in life sciences are welcome to apply if they have experience in one of the above disciplines. Familiarity with micro-/nanofabrication is desirable, but not required. Candidates with a background in life sciences are welcome to apply if they have experience in micro/nanofabrication or related disciplines.
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